منابع مشابه
Lipid-based vehicle for oral drug delivery.
With an increasing number of lipophilic drugs under development, homolipids and heterolipids have gained renewed interests as excipients for oral drug delivery systems. Oral administration has many advantages for chronic drug therapy. It is relatively safe, convenient for the patient and allows self administration. This article is not intended to review the broad area of lipid-based vehicle for...
متن کاملNanostructured lipid carriers: versatile oral delivery vehicle
Oral delivery is the most accepted and economical route for drug administration and leads to substantial reduction in dosing frequency. However, this route still remains a challenge for the pharmaceutical industry due to poorly soluble and permeable drugs leading to poor oral bioavailability. Incorporating bioactives into nanostructured lipid carriers (NLCs) has helped in boosting their therape...
متن کاملEvaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine
Abstract The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol c...
متن کاملEvaluation of Lipid-based Drug Delivery System (Phytosolve) on Oral Bioavailability of Dibudipine
Abstract The objective of present study was to evaluate pharmacokinetic parameters of dibudipine Phytosolve after oral administration in rats. The solubility test was carried out to select suitable oily solvent for dibudipine. Phytosolve formulation was prepared with a medium chain triglyceride (MCT) oil (20%), soybean phospholipids (5%) and a 70% fructose solution (75%). The effect of polyol c...
متن کاملSelf-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations - A Review
More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is...
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ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2001
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2001.008